Dynamic changes of left atrial function during supine ergometry: evidence for interplay with left ventricular function and dynamic changes of pulmonary pressure

Abstract Introduction Despite the pivotal role of left atrial (LA) function in a variety cardiac pathologies, it has been studied mainly at rest. Aim study was to assess effect semisupine exercise ergometry (Ex) on LA function, by volumetric and strain parameters interrogate relationships with ventricular (LV) noninvasive hemodynamics. Patients methods Eighty-two patients (female 26, age: mean/SD 61/15) referred for Ex were studied. The following estimated 2 D echo: LV systolic (LVvolsyst) diastolic (LVvoldiast) volume, ejection fraction (LVEF), stroke volume (LVsv), minimum (LAvolmin) maximal (LAvolmax), emptying [LAEF), reservoir (LAvolres = LAvolmax − LAvolmin), (LAresFR LAvolres/LVsv), conduit (LAcondvol LVsv LAvolres) (LAcondFR LAcondvol/LVsv). (LVSR) (LASR) 2D analysis. Peak tricuspid gradient (TRpg) also estimated. Parameters measured rest R respective % changes (%d) calculated. Results SBE performance efficient achieved target heart rate 73/9 workload Watts 96/21. Systolic blood pressure increased from 139/53 179/31. significant change during are table (all p<0.001). LVSRr LVEFr both related inversely LAvolresR (r=−0.39/p=0.001 r=−0.24/p=0.05) LAresFRr (r=−0.34/p=0.001 r=−0.25/p=0.04). LAcondRFr r=−0.24/p=0.04). LVSR LAvolresEx (r=−0.43/p=0.001). LVSREx (r=−0.24/p=0.04) (r=−0.25/p=0.04). %dLVSR LAEFr %dLVEF LAresFREx (r=−0.27/p=0.03) (r=−0.27/p=0.03). increase TRpg positively r=0.30/p=0.04 LAcondFREx (r=−0.30/p=0.04) (Figure 1). Conclusion induces dynamic spectrum indices. Dynamic function. induced pulmonary pressure, thus further supporting clinical relevance evaluation. Funding Acknowledgement Type funding sources: None.